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- Title
Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy.
- Authors
Chhabra, Akanksha; Ring, Aaron M.; Weiskopf, Kipp; Schnorr, Peter John; Gordon, Sydney; Le, Alan C.; Hye-Sook Kwon; Nan Guo Ring; Volkmer, Jens; Po Yi Ho; Serena Tseng; Weissman, Irving L.; Shizuru, Judith A.
- Abstract
The article presents a study which showed that host hematopoietic stem cell (HSC) clearance is dependent on Fc-mediated antibody effector functions, and enhancing effector activity through blockade of CD47, a myeloid-specific immune checkpoint, extends anti-c-Kit (ACK) conditioning to fully immunocompetent mice. Topics discussed include findings showing that CD47 blockade augments the efficacy of ACK2 for transplant conditioning.
- Subjects
HEMATOPOIETIC stem cells; IMMUNOGLOBULINS; CD47 antigen; BLOOD cells; HEMATOPOIETIC system
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 351, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aae0501