We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.
- Authors
Bea, Jennifer W.; Wassertheil-Smoller, Sylvia; Wertheim, Betsy C.; Klimentidis, Yann; Chen, Zhao; Zaslavsky, Oleg; Manini, Todd M.; Womack, Catherine R.; Kroenke, Candyce H.; LaCroix, Andrea Z.; Thomson, Cynthia A.
- Abstract
Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women’s Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.
- Subjects
AGING; ACE inhibitors; BODY composition; HYPERTENSION; WOMEN'S health; MULTIPLE regression analysis; BODY mass index; CROSS-sectional method; LEAN body mass; SKELETAL muscle; ANGIOTENSIN receptors; PHOTON absorptiometry; OLD age
- Publication
Journal of Aging Research, 2018, p1
- ISSN
2090-2204
- Publication type
Article
- DOI
10.1155/2018/8491092