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- Title
The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading.
- Authors
Raief Mosaad, Basant Mohamed; Ibrahim, Ahmed Samir; Mansour, Mohamed G.; ElAlfy, Mohsen Saleh; Ebeid, Fatma Soliman Elsayed; Abdeldayem, Emad H.
- Abstract
Objectives: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients' laboratory and radiological markers of iron overload. Materials and methods: Sixty-six SCD children and young adults underwent MRI T2* relaxometry using a simple mathematical spreadsheet and laboratory assessment. Results: The results indicated moderate-to-severe hepatic iron overload among 65.2% of studied cases. None had cardiac iron overload. Normal-to-mild iron overload was present in the pancreas in 86% of cases, and 50% had elevated serum ferritin > 2500 ug/L. There was no significant correlation between pancreatic R2* level, serum ferritin, and hepatic iron overload. Patients with higher levels of hemolysis markers and lower pre-transfusion hemoglobin levels showed moderate-to-severe pancreatic iron overload. Conclusion: Chronically transfused patients with SCD have a high frequency of iron overload complications including pancreatic iron deposition, thereby necessitating proper monitoring of the body's overall iron balance as well as detection of extrahepatic iron depositions.
- Subjects
SICKLE cell anemia; IRON; PANCREATIC enzymes; IRON overload; RED blood cell transfusion; BIOMARKERS; PHLEBOTOMY
- Publication
Insights into Imaging, 2022, Vol 13, Issue 1, p1
- ISSN
1869-4101
- Publication type
Article
- DOI
10.1186/s13244-022-01280-x