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- Title
Endometriosis-Related Pain Reduction During Bleeding and Nonbleeding Days in Women Treated with Elagolix.
- Authors
Agarwal, Sanjay K; Singh, Sukhbir S; Archer, David F; Mai, Yabing; Chwalisz, Kristof; Gordon, Keith; Surrey, Eric
- Abstract
7,8 Pain is complex and with women experiencing both pain during bleeding and pain that is not timed with bleeding, it is necessary that medical management of endometriosis addresses both forms of pain. 15 It is probable that endometriosis gives rise to multiple different types of pain including nociceptive, inflammatory, and neuropathic pain, either alone or in combination, and that different pain pathways may be responsible for the different types of pain experienced by women because of endometriosis. Discussion It was previously reported that 6 months of treatment with either elagolix 150 mg QD or 200 mg BID significantly improved dysmenorrhea and nonmenstrual pelvic pain compared with placebo in women with moderate or severe endometriosis-associated pain. 11 As women experience endometriosis-associated pain uniquely, future studies elucidating the mechanism of action of elagolix in women with endometriosis would better our understanding of endometriosis-associated pain and provide insight into the individualization of treatment.
- Subjects
DYSMENORRHEA; PAIN management; HEMORRHAGE; LEVONORGESTREL intrauterine contraceptives; PELVIC pain; TOTAL hip replacement
- Publication
Journal of Pain Research, 2021, Vol 14, p263
- ISSN
1178-7090
- Publication type
Article
- DOI
10.2147/JPR.S284703