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- Title
Dose-Response Effects of Long-Acting Liquid Methylphenidate in Children with Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD): A Pilot Study.
- Authors
Kim, Soo-Jeong; Shonka, Sophia; French, William; Strickland, Jennifer; Miller, Lindsey; Stein, Mark
- Abstract
Attention deficit/hyperactivity disorder (ADHD) symptoms are common in youth with autism spectrum disorders (ASD) and are frequently treated with stimulant medications. Twenty-seven children were randomized to different dose titration schedules, and ADHD symptoms, tolerability, and aberrant behaviors were assessed weekly during a 6-week trial with long-acting liquid methylphenidate (MPH). MPH at low to moderate doses was effective in reducing ADHD symptoms and was well tolerated in young children with ASD and ADHD. Future studies are needed to assess generalization and maintenance of efficacy.
- Subjects
ATTENTION-deficit hyperactivity disorder; AUTISM; DOSE-effect relationship in pharmacology; METHYLPHENIDATE; STATISTICAL sampling; PILOT projects; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2017, Vol 47, Issue 8, p2307
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-017-3125-1