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- Title
Serum lipids modify periodontal infection - interleukin-6 association.
- Authors
Haro, Anniina; Saxlin, Tuomas; Suominen, Anna Liisa; Jula, Antti; Knuuttila, Matti; Ylöstalo, Pekka
- Abstract
Aim The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition. Material and methods This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64 years, dentate, non-diabetic and non-rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4 mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models. Results The number of teeth with deepened periodontal pockets was associated with elevated serum IL-6 levels among subjects with an unfavourable lipid composition (low-density lipoprotein cholesterol ≥3.7 mmol/l or high-density lipoprotein cholesterol <1.3 mmol/l). There was no association between serum TNF-α levels and the number of teeth with deepened periodontal pockets in these data. Conclusion The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.
- Subjects
FINLAND; BLOOD lipids; PERIODONTAL disease; INTERLEUKIN-6; PERIODONTIUM infections; LOW density lipoproteins; INFLAMMATION; TUMOR necrosis factors; HIGH density lipoproteins; PATIENTS; PERIODONTITIS; DEVELOPMENTAL disabilities; HEALTH surveys; INTERLEUKINS; LIPIDS; PERIODONTAL ligament; PERIODONTAL pockets; PERIODONTIUM; TRIGLYCERIDES; CONFOUNDING variables; DIAGNOSIS
- Publication
Journal of Clinical Periodontology, 2017, Vol 44, Issue 3, p275
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12688