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- Title
Deficiency of Lymphocyte Lectin-Dependent Cytotoxicity in Myelodysplastic Syndromes.
- Authors
Fontana, L.; de Sanctis, G.; de Rossi, G.; Bottari, V.; Petti, M.C.; Ensoli, F.; Pasqualetti, D.; Mandelli, F.
- Abstract
We studied a group of patients with myelodysplastic syndromes (MDS) for surface markers and cytotoxic activities of peripheral blood mononuclear cells (PBMNC). The results indicate a significant increase in the total count of CD1 lb + Leu7+ and CD16+ with a percent reduction in CD4+. A reduction in PHA-induced cellular cytotoxicity (PHA-ICC) and NK activity were found. A similar phenotype was found both in refractory anemia (RA) and (RA) with excess of blasts (RAEB/RAEB-t). However, the functional activities reached the normal level only in RA patients; while in RAEB/RAEB-t patients a significant reduction was detected in PHA-ICC and NK activity. Copyright © 1989 S. Karger AG, Basel
- Publication
Acta Haematologica, 1989, Vol 82, Issue 1, p1
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205269