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- Title
Surrogate endpoints and competing risk of death in cardiac arrest research.
- Authors
McCredie, Victoria A.; Scales, Damon C.
- Abstract
We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.
- Subjects
CARDIAC arrest; DEATH; PROGNOSIS; RESEARCH funding
- Publication
Critical Care, 2016, Vol 20, p189
- ISSN
1364-8535
- Publication type
journal article
- DOI
10.1186/s13054-016-1345-y