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- Title
Design and Synthesis of Spirocycles.
- Authors
Kotha, Sambasivarao; Panguluri, Nageswara Rao; Ali, Rashid
- Abstract
In this account we disclose a variety of simple strategies demonstrated in our laboratory in the last two decades for the assembly of diverse and intricate molecular frameworks containing spiro linkage(s) by using various metathesis protocols such as ring-closing metathesis (RCM), ring-opening cross-metathesis (ROCM), ring-closing enyne metathesis (RCEM) and ring-rearrangement metathesis (RRM). Also, cycloaddition reactions ([2+2], [4+2] and [2+2+2]) and other key processes such as Claisen rearrangement (CR), Grignard addition, Fischer indolization (FI), Suzuki-Miyaura (SM) cross-coupling and the retro-Diels-Alder (rDA) reaction have been used as key steps to construct spirocycles.
- Subjects
SPIRO compounds synthesis; METATHESIS reactions; ENYNES; RING formation (Chemistry); SUZUKI reaction
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 36, p5316
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201700439