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- Title
Metabolites from the Euryhaline Ciliate Pseudokeronopsis erythrina.
- Authors
Anesi, Andrea; Buonanno, Federico; di Giuseppe, Graziano; Ortenzi, Claudio; Guella, Graziano
- Abstract
Three new secondary metabolites (named erythrolactones A2, B2 and C2), that are characterized by a central 4-hydroxy-unsaturated δ lactone ring bearing an alkyl saturated chain at C(2) and a butyl-benzenoid group at C(5), together with their respective sulfate esters (erythrolactones A1, B1 and C1), have been isolated from cell cultures of Pseudokeronopsis erythrina, clone TL-1. The structures are assigned on the basis of extensive spectroscopic measurements (1D and 2D NMR, UV, IR and HR-MALDI-TOF). A plausible biogenetic route for their formation is also suggested. Cold-shock treatment was performed in order to induce the discharge of the metabolites contained in pigment granules lying on the ciliary organelles of this microorganism. HPLC-ESI-MS analysis of this granule discharge reveals that erythrolactones A2-C2 are actually therein contained, strongly suggesting a possible role for these metabolites in the chemical defence strategy of P. erythrina.
- Subjects
METABOLITES; SULFATES; LACTONES; DNA damage; PROTOZOA; NUCLEAR magnetic resonance
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 7, p1330
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501424