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- Title
Antipsychotic exposure prior to acute myocardial infarction in patients with serious mental illness.
- Authors
Wu, S.‐I.; Kao, K.‐L.; Chen, S.‐C.; Juang, J. J. M.; Lin, C.‐J.; Fang, C.‐K.; Wu, C.‐S.; Dewey, M.; Prince, M. J.; Stewart, R.
- Abstract
Objective To investigate the association between acute myocardial infarction ( AMI) and recent exposure to antipsychotic agents in people with serious mental illness ( SMI), and modifying influences. Method A case-crossover design was applied using the Taiwan National Health Insurance Research Database ( NHIRD) to compare the exposure frequency of antipsychotic agents within individuals of schizophrenia or bipolar disorder between 60-day case and control periods prior to their first AMI episode during 1996-2007. Results A sample of 834 patients with incident AMI was analysed. AMI was significantly associated with more recent antipsychotic exposure in schizophrenia after adjustment ( OR 1.87, 95% confidence interval 1.15-3.03) bipolar disorder ( OR 1.06, 0.51-2.21). This association in schizophrenia was significantly stronger in men and in patients without previous diagnoses of cardiovascular risk factors. Conclusion These findings are consistent with a short-term risk effect of antipsychotic exposure on risk of AMI and identify potentially vulnerable groups. Further research is required to clarify underlying biological mechanisms.
- Subjects
MYOCARDIAL infarction; ANTIPSYCHOTIC agents; MENTAL illness; BRAIN diseases; PSYCHIATRIC research; NECROSIS
- Publication
Acta Psychiatrica Scandinavica, 2015, Vol 131, Issue 3, p213
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12345