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- Title
Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells.
- Authors
Farzaneh, Maryam; Nasrolahi, Ava; Ghaedrahmati, Farhoodeh; Masoodi, Tariq; Najafi, Sajad; Sheykhi-Sabzehpoush, Mohadeseh; Dari, Mahrokh Abouali Gale; Radoszkiewicz, Klaudia; Uddin, Shahab; Azizidoost, Shirin; Khoshnam, Seyed Esmaeil
- Abstract
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
- Publication
Clinical & Translational Oncology, 2023, Vol 25, Issue 7, p2015
- ISSN
1699-048X
- Publication type
Article
- DOI
10.1007/s12094-023-03110-y