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- Title
Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion.
- Authors
Figueira, Estela Regina Ramos; Rocha-Filho, Joel Avancini; Lanchotte, Cinthia; Coelho, Ana Maria Mendonça; Nakatani, Mauro; Tatebe, Eduardo Ryoiti; Lima, Jonathan Augusto Venceslau; Mendes, Camilla Oliveira; de Araujo, Bruno Camargo Rocha Paim; Abdo, Emilio Elias; D'Albuquerque, Luiz Carneiro; Galvão, Flavio Henrique Ferreira
- Abstract
Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
- Subjects
SEVOFLURANE; REPERFUSION; ACID-base imbalances; ISCHEMIA; LIVER
- Publication
Gastroenterology Research & Practice, 2019, p1
- ISSN
1687-6121
- Publication type
Article
- DOI
10.1155/2019/5758984