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- Title
Epigenetics in the heart: the role of histone modifications in cardiac remodelling.
- Authors
Tingare, Asmita; Thienpont, Bernard; Roderick, H. Llewelyn
- Abstract
Understanding the molecular mechanisms underlying cardiac development and growth has been a longstanding goal for developing therapies for cardiovascular disorders. The heart adapts to a rise in its required output by an increase in muscle mass and alteration in the expression of a large number of genes. However, persistent stress diminishes the plasticity of the heart, consequently resulting in its maladaptive growth, termed pathological hypertrophy. Recent developments suggest that the concomitant genome-wide remodelling of the gene expression programme is largely driven through epigenetic mechanisms such as post-translational histone modifications and DNA methylation. In the last few years, the distinct functions of histone modifications and of the enzymes catalysing their formation have begun to be elucidated in processes important for cardiac development, disease and cardiomyocyte proliferation. The present review explores how repressive histone modifications, in particular methylation of H3K9 (histone H3 Lys9), govern aspects of cardiac biology.
- Subjects
EPIGENETICS; CARDIOVASCULAR disease treatment; DNA methylation; HYPERTROPHY; GENE expression; HEART cells; MUSCLE cells
- Publication
Biochemical Society Transactions, 2013, Vol 41, Issue 3, p789
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20130012