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- Title
Add‐On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (ADVANCE): A Partially Randomized Patient Preference Trial.
- Authors
Suresh, Hrishikesh; Mithani, Karim; Warsi, Nebras; Ochi, Ayako; Otsubo, Hiroshi; Drake, James M.; Rutka, James T.; Kerr, Elizabeth; Smith, Mary Lou; Breitbart, Sara; Yau, Ivanna; McRae, Lyndsey; Chau, Vann; Weiss, Shelly; Jain, Puneet; Donner, Elizabeth; Fasano, Alfonso; Gorodetsky, Carolina; Ibrahim, George M.
- Abstract
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug‐resistant epilepsy. The added value of deep brain stimulation (DBS) instead of continued VNS optimization is unknown. In a prospective, non‐blinded, randomized patient preference trial of 18 children (aged 8–17 years) who did not respond to VNS after at least 1 year, add‐on DBS resulted in greater seizure reduction compared with an additional year of VNS optimization (51.9% vs. 12.3%, p = 0.047). Add‐on DBS also resulted in less bothersome seizures (p = 0.03), but no change in quality of life. DBS may be considered earlier for childhood epilepsy after non‐response to VNS. ANN NEUROL 2024;96:405–411
- Subjects
VAGUS nerve stimulation; DEEP brain stimulation; CHILDHOOD epilepsy; PATIENT preferences; VAGUS nerve; CHILDREN with epilepsy
- Publication
Annals of Neurology, 2024, Vol 96, Issue 2, p405
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.26956