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- Title
Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women.
- Authors
Søndergaard, Esben; Nellemann, Birgitte; Sørensen, Lars P.; Gormsen, Lars C.; Christiansen, Jens S.; Ernst, Erik; Dueholm, Margit; Nielsen, Søren
- Abstract
OBJECTIVE--Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat. RESEARCH DESIGN ANDMETHODS--Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference ~80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-³H]-triolein--labeled VLDL. RESULTS--VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = 20.89, P = 0.02) and LBSQ (r = 20.87, P = 0.02) fat. CONCLUSIONS--VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.
- Subjects
METABOLIC disorders; OBESITY; LIPID metabolism; LIPOPROTEINS; PREBIOTICS
- Publication
Diabetes, 2011, Vol 60, Issue 11, p2787
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db11-0604