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- Title
The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population.
- Authors
Xiang Cheng; Lisong Shi; Shaofang Me; Fan Wang; Xiuchun Li; Chengqi Xu; Pengyun Wang; Baofeng Yang; Qingxian Li; Zhenwei Pan; Yue Li; Hao Xia; Chenhong Zheng; Yuhe Ke; Yanxia Wu; Tingting Tang; Xinxin Yan; Yan Yang; Ni Xia; Rui Yao
- Abstract
OBJECTIVE--Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GenelD Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease. RESEARCH DESIGN AND METHODS--Three SNPs (rs2383208, rslO811661, and rsl0757283) were genotyped in two GenelD cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies. RESULTS--The association between two of the three SNPs and type 2 diabetes was replicated in the GenelD population (rs2383208, P = 0.936; rslO811661-T, P = 0.02, odds ratio [OR] = 1.23; rsl0757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rslO811661-T, P = 0.002, OR = 1.19; rsl0757283-C, P = 0.003, OR = 1.18). In addition, rsl0757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002). CONCLUSIONS--For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rslO811661 and rsl0757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GenelD Chinese Han population.
- Subjects
GENOMES; TYPE 2 diabetes; CHINESE people; GENETIC polymorphisms; CORONARY disease; LOGISTIC regression analysis
- Publication
Diabetes, 2011, Vol 60, Issue 2, p680
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db10-0185