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- Title
Circulating Endothelial Progenitor Cells (EPCs) in Subjects with Impaired Glucose Regulation (Pre-Diabetes).
- Authors
Pucci, Laura; Lucchesi, Daniela; Iorio, Maria C.; Vanacore, Renato; di Stefano, Rosella; Fotino, Carmen; Triscornia, Stefano; Balberini, Alberto; Miccoli, Roberto; Penno, Giuseppe; del Prato, Stefano
- Abstract
Cumulative cardiovascular risk, and cardiovascular disease status alter number and function of circulating endothelial progenitor cells (EPCs). Furthermore, circulating EPCs levels predict cardiovascular events. Diabetes reduces circulating EPCs level. In this scenario, our purpose was to investigate whether pre-diabetes impacts on progenitor cells (CPCs) and EPCs levels. A group of 27 pre-diabetic subjects (8 subjects with impaired fasting glucose, IFG; 14 with impaired glucose tolerance, IGT; and 5 with both IFG and IGT) and a group 22 control individuals have been recruited. No subject was on pharmacological treatments. BMI, waist, OGTT, HbA1c, blood pressure, lipids and inflammatory parameters were measured. Metabolic syndrome (MS) was assessed by NCEP/ATPIII criteria. CPCs (CD34+ cells) and EPCs (CD34+KDR+ cells) were assessed by FACS analysis. Data are expressed as cells number for ml by ISHAGE protocol and as EPCs/CPCs ratio. No differences were observed in EPCs and in EPCs/CPCs in pre-diabetics compared with controls (EPCs: 532±424 vs 511±348/ml, p=0.86; EPCs/CPCs: 28.0±16.1 vs 22.9±17.2%, p--0.30). No correlations were observed between EPCs or EPCs/CPCs and clinical (age, BMI, waist, blood pressure) or laboratory parameters (fasting or 2-h glucose, HbA1c, glucose area trader OGTT, lipids, hs-CRP). In pre-diabetic subjects, EPCs (516±298 vs 542±494/ml, p=0.88) and EPCs/CPCs (27.6±16.4 vs 28.3±16.4%, p=0.93) were superimposable in those with (n. 11, 40%) and without MS. All control subjects were free of MS. A positive first-degree family history for diabetes was present in 10 controls (45%) and 19 pre-diabetic subjects (70%). EPCs (436±334 vs 651±-432/ml, p=0.067) and EPCs/CPCs (21.9±14.3 vs 31.1± 18.5%, p=0.069) were lower in subjects with a family history for diabetes. In conclusions, minor impairments of glucose regulation (pre-diabetes) do not affect circulating EPCs. In pre-diabetic subjectss, EPCs levels are not modified by the co-occurrence of the Metabolic Syndrome.
- Subjects
CARDIOVASCULAR diseases; ENDOTHELIUM; BLOOD sugar; DIABETES complications; PEOPLE with diabetes; GLUCOSE tolerance tests; METABOLIC syndrome
- Publication
Diabetes, 2007, Vol 56, pA194
- ISSN
0012-1797
- Publication type
Article