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- Title
Human Umbilical Cord Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Reduce Skin Inflammation In Vitro.
- Authors
Lin, Tzou-Yien; Chang, Tsong-Min; Tsai, Wei-Cheng; Hsieh, Yi-Ju; Wang, Li-Ting; Huang, Huey-Chun
- Abstract
The protective roles of extracellular vesicles derived from human umbilical cord mesenchymal stem cells against oxazolone-induced damage in the immortalized human keratinocyte cell line HaCaT were investigated. The cells were pretreated with or without UCMSC-derived extracellular vesicles 24 h before oxazolone exposure. The pretreated UVMSC-EVs showed protective activity, elevating cell viability, reducing intracellular ROS, and reducing the changes in the mitochondrial membrane potential compared to the cells with a direct oxazolone treatment alone. The UCMSC-EVs exhibited anti-inflammatory activity via reducing the inflammatory cytokines IL-1β and TNF-α. A mechanism study showed that the UCMSC-EVs increased the protein expression levels of SIRT1 and P53 and reduced P65 protein expression. It was concluded that UVMSC-EVs can induce the antioxidant defense systems of HaCaT cells and that they may have potential as functional ingredients in anti-aging cosmetics for skin care.
- Subjects
EXTRACELLULAR vesicles; SKIN inflammation; MESENCHYMAL stem cells; MEMBRANE potential; SKIN care; UMBILICAL cord
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 23, p17109
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242317109