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- Title
Thrombotic Mechanism Involving Platelet Activation, Hypercoagulability and Hypofibrinolysis in Coronavirus Disease 2019.
- Authors
Wada, Hideo; Shiraki, Katsuya; Shimpo, Hideto; Shimaoka, Motomu; Iba, Toshiaki; Suzuki-Inoue, Katsue
- Abstract
Coronavirus disease 2019 (COVID-19) has spread, with thrombotic complications being increasingly frequently reported. Although thrombosis is frequently complicated in septic patients, there are some differences in the thrombosis noted with COVID-19 and that noted with bacterial infections. The incidence (6–26%) of thrombosis varied among reports in patients with COVID-19; the incidences of venous thromboembolism and acute arterial thrombosis were 4.8–21.0% and 0.7–3.7%, respectively. Although disseminated intravascular coagulation (DIC) is frequently associated with bacterial infections, a few cases of DIC have been reported in association with COVID-19. Fibrin-related markers, such as D-dimer levels, are extremely high in bacterial infections, whereas soluble C-type lectin-like receptor 2 (sCLEC-2) levels are high in COVID-19, suggesting that hypercoagulable and hyperfibrinolytic states are predominant in bacterial infections, whereas hypercoagulable and hypofibrinolytic states with platelet activation are predominant in COVID-19. Marked platelet activation, hypercoagulability and hypofibrinolytic states may cause thrombosis in patients with COVID-19.
- Subjects
BLOOD platelet activation; COVID-19; BACTERIAL diseases; DISSEMINATED intravascular coagulation; THROMBOEMBOLISM
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 9, p7975
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24097975