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- Title
Therapeutic Implications of microRNAs in Depressive Disorders: A Review.
- Authors
Hassan, Mubashir; Amir, Aqsa; Shahzadi, Saba; Kloczkowski, Andrzej
- Abstract
MicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that interfere with a person's everyday activities. In this review, we have focused on exploration of the significant role of miRNAs in depression by affecting associated target proteins (cellular and synaptic) and their signaling pathways which can be controlled by the attachment of miRNAs at transcriptional and translational levels. Moreover, miRNAs have potential role as biomarkers and may help to cure depression through involvement and interactions with multiple pharmacological and physiological therapies. Taken together, miRNAs might be considered as promising novel therapy targets themselves and may interfere with currently available antidepressant treatments.
- Subjects
MENTAL depression; MICRORNA; AFFECTIVE disorders; ANGER management; ANXIETY disorders; CELLULAR signal transduction
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 21, p13530
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232113530