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- Title
Waldenström Macroglobulinemia: Mechanisms of Disease Progression and Current Therapies.
- Authors
Boutilier, Ava J.; Huang, Lina; Elsawa, Sherine F.
- Abstract
Waldenström macroglobulinemia is an indolent, B-cell lymphoma without a known cure. The bone marrow microenvironment and cytokines both play key roles in Waldenström macroglobulinemia (WM) tumor progression. Only one FDA-approved drug exists for the treatment of WM, Ibrutinib, but treatment plans involve a variety of drugs and inhibitors. This review explores avenues of tumor progression and targeted drug therapy that have been investigated in WM and related B-cell lymphomas.
- Subjects
UNITED States. Food &; Drug Administration; DISEASE progression; CANCER invasiveness; DRUG therapy; LYMPHOMAS; DRUGS; RITUXIMAB; BONE marrow
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 19, p11145
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231911145