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- Title
Diet-Regulating Microbiota and Host Immune System in Liver Disease.
- Authors
Eom, Jung A; Kwon, Goo Hyun; Kim, Na Yeon; Park, Eun Ju; Won, Sung Min; Jeong, Jin Ju; Raja, Ganesan; Gupta, Haripriya; Asmelash Gebru, Yoseph; Sharma, Satyapriya; Choi, Ye Rin; Kim, Hyeong Seop; Yoon, Sang Jun; Hyun, Ji Ye; Jeong, Min Kyo; Park, Hee Jin; Min, Byeong Hyun; Choi, Mi Ran; Kim, Dong Joon; Suk, Ki Tae
- Abstract
The gut microbiota has been known to modulate the immune responses in chronic liver diseases. Recent evidence suggests that effects of dietary foods on health care and human diseases are related to both the immune reaction and the microbiome. The gut-microbiome and intestinal immune system play a central role in the control of bacterial translocation-induced liver disease. Dysbiosis, small intestinal bacterial overgrowth, translocation, endotoxemia, and the direct effects of metabolites are the main events in the gut-liver axis, and immune responses act on every pathways of chronic liver disease. Microbiome-derived metabolites or bacteria themselves regulate immune cell functions such as recognition or activation of receptors, the control of gene expression by epigenetic change, activation of immune cells, and the integration of cellular metabolism. Here, we reviewed recent reports about the immunologic role of gut microbiotas in liver disease, highlighting the role of diet in chronic liver disease.
- Subjects
ENDOTOXEMIA; SMALL intestinal bacterial overgrowth; LIVER diseases
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 12, p6326
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22126326