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- Title
Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes.
- Authors
Grieco, Giuseppina Emanuela; Brusco, Noemi; Licata, Giada; Nigi, Laura; Formichi, Caterina; Dotta, Francesco; Sebastiani, Guido
- Abstract
Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.
- Subjects
OXIDATIVE stress; REGULATOR genes; DIABETES complications; DIABETES; METABOLIC disorders; OFF-label use (Drugs)
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 24, p6358
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20246358