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- Title
New Insights into the Role of Epithelial–Mesenchymal Transition during Aging.
- Authors
Santos, Francisco; Moreira, Cristiana; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, Bruno
- Abstract
Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
- Subjects
EPITHELIAL cells; AGING; FIBROSIS; STEM cells; PHENOTYPES
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 4, p891
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20040891