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- Title
The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion.
- Authors
Mojic, Marija; Takeda, Kazuyoshi; Hayakawa, Yoshihiro
- Abstract
Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important effector molecule of anti-tumor immunity, capable of suppressing tumor growth through various mechanisms. On the contrary to such a bright side of IFN-γ, it has also been involved in promoting an outgrowth of tumor cells with immunoevasive phenotype suggesting an existence of a dark "tumor-promoting" side effect of IFN-γ. In this review, we will summarize this multi-functional role of IFN-γ in tumor context, how it promotes changes in tumor phenotype towards increased fitness for growth in immunocompetent host. Furthermore, we summarize how IFN-γ is involved in homeostatic or cancer-triggered mechanisms to establish an immunosuppressive tumor microenvironment.
- Subjects
THERAPEUTIC use of interferons; INTERFERONS; ANTINEOPLASTIC agents; CANCER cells; TUMOR growth; IMMUNOSUPPRESSION
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 1, p89
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19010089