We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity.
- Authors
Vasileiou, Panagiotis V. S.; Mourouzis, Iordanis; pantos, Constantinos
- Abstract
Mitochondria have emerged as key players regarding cellular homeostasis not only due to their contribution regarding energy production through oxidative phosphorylation, but also due to their involvement in signaling, ion regulation, and programmed cell death. Indeed, current knowledge supports the notion that mitochondrial dysfunction is a hallmark in the pathogenesis of various diseases. Mitochondrial biogenesis and function require the coordinated action of two genomes: nuclear and mitochondrial. Unfortunately, both intrinsic and environmental genotoxic insults constantly threaten the integrity of nuclear as well as mitochondrial DNA. Despite the extensive research that has been made regarding nuclear genome instability, the importance of mitochondrial genome integrity has only recently begun to be elucidated. The specific architecture and repair mechanisms of mitochondrial DNA, as well as the dynamic behavior that mitochondria exert regarding fusion, fission, and autophagy participate in mitochondrial genome stability, and therefore, cell homeostasis
- Subjects
MITOCHONDRIA; HOMEOSTASIS; OXIDATIVE phosphorylation; PHOSPHORYLATION; CELL death
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 8, p1821
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18081821