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- Title
Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation.
- Authors
Rashid, Farooq; Awan, Hassaan Mehboob; Shah, Abdullah; Liang Chen; Ge Shan
- Abstract
MicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 (APC2), a tumor suppressor and a negative regulator of Wnt signaling, was found to be the direct target of miR-3648. Levels of APC2 were downregulated when cells were under ER stress or after overexpressing miR-3648. Inhibition of miR-3648 by antagomir increased APC2 levels and decreased cell proliferation. Conversely, when miR-3648 was overexpressed, APC2 levels were decreased and the cell growth increased. Our data demonstrated that ER stress mediated induction of miR-3648 in human cells, which then downregulated APC2 to increase cell proliferation.
- Subjects
ENDOPLASMIC reticulum; ADENOMATOUS polyposis coli; CELL proliferation; WNT genes; WNT signal transduction
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 7, p1375
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18071375