We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice.
- Authors
Youngjoo Lee; Sun-A Im; Jiyeon Kim; Sungwon Lee; Junghak Kwon; Heetae Lee; Hyunseok Kong; Youngcheon Song; Eunju Shin; Seon-Gil Do; Chong-Kil Lee; Kyungjae Kim
- Abstract
Chronic stress generally experienced in our daily lives; is known to augment disease vulnerability by suppressing the host immune system. In the present study; the effect of modified Aloe polysaccharide (MAP) on chronic stress-induced immunosuppression was studied; this Aloe compound was characterized in our earlier study. Mice were orally administered with MAP for 24 days and exposed to electric foot shock (EFS; duration; 3 min; interval; 10 s; intensity; 2 mA) for 17 days. The stress-related immunosuppression and restorative effect of MAP were then analyzed by measuring various immunological parameters. MAP treatment alleviated lymphoid atrophy and body weight loss. The numbers of lymphocyte subsets were significantly normalized in MAP-treated mice. Oral administration of MAP also restored the proliferative activities of lymphocytes; ovalbumin (OVA)-specific T cell proliferation; antibody production; and the cell killing activity of cytotoxic T lymphocytes. In summary; oral administration of MAP ameliorated chronic EFS stress-induced immunosuppression.
- Subjects
POLYSACCHARIDES; IMMUNOSUPPRESSION; LABORATORY mice; IMMUNE reconstitution inflammatory syndrome; CYTOTOXIC T cells
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 10, p1660
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17101660