We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Reconstruction and Application of Protein-Protein Interaction Network.
- Authors
Tong Hao; Wei Peng; Qian Wang; Bin Wang; Jinsheng Sun
- Abstract
The protein-protein interaction network (PIN) is a useful tool for systematic investigation of the complex biological activities in the cell. With the increasing interests on the proteome-wide interaction networks, PINs have been reconstructed for many species, including virus, bacteria, plants, animals, and humans. With the development of biological techniques, the reconstruction methods of PIN are further improved. PIN has gradually penetrated many fields in biological research. In this work we systematically reviewed the development of PIN in the past fifteen years, with respect to its reconstruction and application of function annotation, subsystem investigation, evolution analysis, hub protein analysis, and regulation mechanism analysis. Due to the significant role of PIN in the in-depth exploration of biological process mechanisms, PIN will be preferred by more and more researchers for the systematic study of the protein systems in various kinds of organisms.
- Subjects
PROTEIN-protein interactions; PROTEOMICS; BIOLOGICAL networks; GENE regulatory networks; PROTEIN synthesis
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 6, p907
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17060907