We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study.
- Authors
McCabe, Paul S.; Pye, Stephen R.; Mc Beth, John; Lee, David M.; Tajar, Abdelouahid; Bartfai, Gyorgy; Bouillon, Roger; Casanueva, Felipe; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Pendleton, Neil; Punab, Margus; Vanderschueren, Dirk; Wu, Frederick C.; O'Neill, Terence W.; Beth, John Mc; Boonen, Steven
- Abstract
<bold>Background: </bold>The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men.<bold>Methods: </bold>Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP.<bold>Results: </bold>Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5%) developed new CWP at follow up and 577 (24.9%) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95% CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95% CI = 0.93-3.02) or depression (OR = 1.77; 95% CI = 0.98-3.21), however rendered the association non-significant.<bold>Conclusions: </bold>Low vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.
- Subjects
MENTAL depression; THERAPEUTICS; OBESITY genetics; EPIDEMIOLOGICAL research; CHRONIC pain; PATIENT compliance; PROGNOSIS
- Publication
BMC Musculoskeletal Disorders, 2016, Vol 17, p1
- ISSN
1471-2474
- Publication type
journal article
- DOI
10.1186/s12891-016-0881-6