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- Title
NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.
- Authors
Sung-Hoon Park; Dutta, Noton Kumar; Mm-Won Baek; Dong-Jae Kim; Yi-Rang Na; Seung-Hyeok Seok; Byoung-Hee Lee; Ji-Eun Cho; Geon-Sik Cho; Jae-Hak Park
- Abstract
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na+ excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.
- Subjects
CHITOSAN; BLOOD pressure; RATS; NITROGEN excretion; UREA
- Publication
Journal of Veterinary Science, 2009, Vol 10, Issue 2, p141
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2009.10.2.141