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- Title
Cyclopropenes for the Synthesis of Cyclopropane-Fused Dihydroquinolines and Benzazepines.
- Authors
Luo, Hui ‐ Xin; Niu, You ‐ Hong; Cao, Xiao ‐ Ping; Ye, Xin ‐ Shan
- Abstract
An efficient method for the construction of cyclopropane-fused dihydroquinolines was established by a novel Povarov-type three-component reaction of aromatic aldehydes, anilines and cyclopropenes in the presence of trifluoromethanesulfonic acid. The reaction proceeded in a regioselective and diastereoselective manner. Furthermore, the dihydroquinolines were smoothly converted to benzazepine derivatives via a ring opening/isomerization sequence, further expanding the synthetic scope.
- Subjects
CYCLOPROPANE; CYCLOPROPANATION; PROPANE; BENZAZEPINES; CHEMICAL synthesis; CATALYSIS
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 13, p2893
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500203