We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma.
- Authors
Hoffman, Daniel I.; Abdullah, Kalil G.; McCoskey, Makayla; Binder, Zev A.; O'Rourke, Donald M.; Desai, Arati S.; Nasrallah, MacLean P.; Bigdeli, Ashkan; Morrissette, Jennifer J. D.; Brem, Steven; Bagley, Stephen J.
- Abstract
Purpose: Young adults with isocitrate-dehydrogenase wild-type (IDH-WT) glioblastoma (GBM) represent a rare, understudied population compared to pediatric high-grade glioma, IDH-mutant GBM, or IDH-WT GBM in older patients. We aimed to explore the prognostic impact of epidermal growth factor receptor copy number gain (EGFR CN gain), one of the most common genetic alterations in IDH-WT glioma, in young adults with IDH-WT GBM. Methods: We performed a retrospective cohort study of patients 18–45 years old with newly diagnosed, IDH-WT GBM whose tumors underwent next-generation sequencing at our institution between 2014 and 2018. The impact of EGFR CN gain on time to tumor progression (TTP) and overall survival (OS) was assessed. A validation cohort of patients 18–45 years old with IDH-WT GBM was analyzed from The Cancer Genome Atlas (TCGA). Results: Ten of 28 patients (36%) from our institution had EGFR CN gain, which was associated with shorter TTP (median 6.5 vs. 11.9 months; p = 0.06) and OS (median 16.3 vs. 23.5 months; p = 0.047). The negative prognostic impact of EGFR CN gain on OS persisted in a multivariate model (HR 6.40, 95% CI 1.3–31.0, p = 0.02). In the TCGA cohort (N = 43), EGFR CN gain was associated with shorter TTP and worse OS, although these did not reach statistical significance (TTP, median 11.5 vs. 14.4 months, p = 0.18; OS, median 23.6 vs. 27.8 months; p = 0.18). Conclusions: EGFR CN gain may be associated with inferior outcomes in young adults with newly diagnosed, IDH-WT GBM, suggesting a potential role for targeting EGFR in this population.
- Subjects
EPIDERMAL growth factor receptors; ISOCITRATE dehydrogenase; OLIGODENDROGLIOMAS; YOUNG adults
- Publication
Journal of Neuro-Oncology, 2019, Vol 145, Issue 2, p321
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-019-03298-6