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- Title
Despite aggressive histopathology survival is not impaired in young patients with colorectal cancer.
- Authors
Schellerer, Vera; Merkel, Susanne; Schumann, Silke; Schlabrakowski, Anne; Förtsch, Thomas; Schildberg, Claus; Hohenberger, Werner; Croner, Roland
- Abstract
Purpose: Colorectal carcinoma (CRC) is generally a disease of persons older than 50 years. Concerning younger patients, controversies still exist regarding features and prognosis of CRC. We performed this study to characterize CRC in young patients (≤50 years) as well as to evaluate outcome in comparison with older patients (>50 years) with CRC. Methods: Clinical and histopathological parameters of 244 patients aged 50 years or less were compared with 1,718 patients aged more than 50 years. Results: Compared with older patients, the younger had less adenocarcinomas (82.8% vs. 89.1%; p = 0.004) and less postoperative complications (18.4% vs. 28.7%; p = 0.001), and less Union Internationale Contre le Cancer stage I colon cancers (22.9% vs. 13.6%, p = 0.046) but elevated overall 5-year survival rates for M0 colon and rectal cancers ( p = 0.005; p < 0.001). In young patients, the minority suffered from hereditary cancer syndromes (7.4%) and inflammatory bowel diseases (7.0%). Furthermore, up to 40% of young patients denied any cancers in their families. Cancer-related survival rates were significantly elevated in young patients with M0 rectal carcinoma ( p = 0.014), whereas in M0 colon cancers, no differences were detectable ( p = 0.542). In case of the presence of distant metastases, overall and cancer-related survival rates were similar in old and young patients. Conclusion: Although young patients present with more aggressive histopathological subtypes and less early stages, cancer-related survival is not less favourable compared with older patients.
- Subjects
COLON cancer; HEALTH outcome assessment; AGE factors in disease; HISTOPATHOLOGY; INFLAMMATORY bowel diseases; SURGICAL complications
- Publication
International Journal of Colorectal Disease, 2012, Vol 27, Issue 1, p71
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-011-1291-8