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- Title
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
- Authors
E. Hattingen; U. Pilatus; M. Kieslich; B. Yan; D. Schwabe; F. Zanella; H. Lanfermann
- Abstract
AbstractBackground??Diagnosis of brainstem lesions in children based on magnetic resonance imaging alone is a challenging problem. Magnetic resonance spectroscopy (MRS) is a noninvasive technique for spatial characterization of biochemical markers in tissues and gives information regarding cell membrane proliferation, neuronal damage, and energy metabolism.Methods??We measured the concentrations of biochemical markers in five children with brainstem lesions and evaluated their potential diagnostic significance. Images and spectra were acquired on a 1.5-T imager. The concentrations ofN-acetylaspartate, tetramethylamines (e.g., choline), creatine, phosphocreatine, lactate, and lipids were measured within lesions located at the brainstem using Point-resolved spectroscopy sequences.Results??Diagnosis based on localized proton spectroscopy included brainstem glioma, brainstem encephalitis, demyelination, dysmyelination secondary to neurofibromatosis type 1 (NF 1), and possible infection or radiation necrosis. In all but one patient, diagnosis was confirmed by biopsy or by clinical follow-up.Conclusions??This small sample of patients suggests that MRS is important in the differential diagnosis between proliferative and nonproliferative lesions in patients without neurofibromatosis. Unfortunately, in cases of NF 1, MRS can have a rather misdiagnosis role.
- Subjects
PROTON magnetic resonance spectroscopy; BRAIN stem diseases; BIOMARKERS; JUVENILE diseases
- Publication
Child's Nervous System, 2007, Vol 23, Issue 3, p305
- ISSN
0256-7040
- Publication type
Article