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- Title
Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia.
- Authors
Emmett, Sarah; Jenkins, Glenn; Boros, Samuel; Whiteman, David C.; Panizza, Benedict; Antonsson, Annika
- Abstract
Background While human papillomavirus ( HPV) is an accepted risk factor for oropharyngeal squamous cell carcinoma ( SCC), its aetiological role in oral cavity SCC remains unclear. This study aimed to determine the HPV prevalence in an Australian population. Methods DNA was extracted from 63 formalin-fixed paraffin-embedded tumour specimens histologically confirmed as SCC of the oral cavity, diagnosed during 2006-2012. Clinical data were extracted from medical records. HPV presence was determined by polymerase chain reaction. Positive samples were typed by sequencing. Immunohistochemistry was used to assess p16INK4A , p53, pRB, Ki67, Cyclin D1 and p21WAF1 expression. Results Five of the 63 tumours (8%) were positive for HPV DNA (three HPV-16 positive and two HPV-18 positive). Two tumours overexpressed p16INK4A (3%) and one of these was also HPV positive. Overexpression of Cyclin D1 correlated significantly with tumour recurrence ( P = 0.029) and death ( P = 0.002). Conclusions This study has identified a low prevalence of high-risk HPV in Queensland, Australia.
- Subjects
PAPILLOMAVIRUSES; SQUAMOUS cell carcinoma; CYCLIN-dependent kinase inhibitor-2A; ORAL diseases; POLYMERASE chain reaction
- Publication
ANZ Journal of Surgery, 2017, Vol 87, Issue 9, p714
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/ans.13607