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- Title
Otoimmün Hepatit Hastalarında Tek Merkez Tedavi Deneyimi.
- Authors
Sütçüoğlu, Osman; Sargın, Zeynep Gök; Haghighi, Naser Alizadeh; Yüceldi, Selma Demirbaş; Karataş, Ali; Önal, İbrahim Koral; Dumlu, Şükrü; Özenirler, Seren; Cindoruk, Mehmet; Doğan, İbrahim; Karakan, Tarkan; Arhan, Mehmet; İbiş, Mehmet
- Abstract
Aim: The aim of the study was to evaluate the efficacy of therapeutic regimens in autoimmune hepatitis (AIH). Methods: Clinical and demographical data of AIH patients including the therapeutic regimens given and the response to treatment were retrospectively evaluated. Results: Sixty-one out of 66 patients (92.4%) were treated with a combination of azathiopurine (AZA) and corticosteroids; 45 patients (73.8%) had a complete response. In 21 patients (34%) on combination therapy the treatment was modified due to nonresponse (16 patients) or side effects (5 patients) and mycophenolate mofetil (MMF) was initiated in 10 patients (16%) as a second line therapy. In MMF group; 8 patients (80%) had complete, 1 patient (10%) had incomplete response and 2 patients had leucopenia but no cessation of treatment. Conclusion: Complete response can not be obtained in approximately one fourth of patients with AZA and corticosteroid combination. Alternative treatments are limited but MMF seems to be promising in this regard.
- Publication
Gazi Medical Journal, 2017, Vol 28, Issue 3, p174
- ISSN
1300-056X
- Publication type
Article
- DOI
10.12996/gmj.2017.53