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- Title
Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future?
- Authors
Nguyen Thi Hoang Mai; Nguyen Hoan Phu; Le Nguyen Truc Nhu; Nguyen Thi Thu Hong; Nguyen Ho Hong Hanh; Lam Anh Nguyet; Tran My Phuong; McBride, Angela; Do Quang Ha; Ho Dang Trung Nghia; Nguyen Van Vinh Chau; Thwaites, Guy; Le Van Tan
- Abstract
Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.
- Subjects
JAPANESE encephalitis viruses; NUCLEOTIDE sequencing; POLYMERASE chain reaction
- Publication
Open Forum Infectious Diseases, 2017, Vol 4, Issue 1, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofx046