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- Title
Blood protein reactions to ablation of capsaicin-sensitive neurons.
- Authors
N. Kostina; V. Spiridonov
- Abstract
The effects of ablation of afferent neurons with neurotoxic doses of capsaicin (150 mg/kg) on protein levels in plasma fractions were studied by polyacrylamide gel electrophoresis in Wistar rats at different times points after administration of capsaicin and in inflammatory reactions induced by zymosan (10 mg/100 g). Administration of neurotoxic doses of capsaicin induced biphasic changes in protein levels in plasma fractions. During the initial period (up to seven days), “acute-type” changes in protein content were seen; at 11–30 days, there were chronic increases in the albumin level with decreases in α1, α2, and γ globulins. Defunctionalization of capsaicin-sensitive nerves 14–30 days before induction of inflammation prevented the “acute-phase” changes in protein contents in the albumin, α1, α2, and β globulin fractions in response to induction of inflammation with zymosan.
- Publication
Neuroscience & Behavioral Physiology, 2006, Vol 36, Issue 7, p737
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-006-0081-1