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- Title
Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13.
- Authors
Peng, Xiao-Ping; Li, Gang; Wang, Li-Mei; Wang, Qi; Wang, Cong; Ji, Li-Xia; Cao, Chen-Xi; Lin, Guo-Feng; Jiang, Zu-Yang; He, Zhuo-qian; Wang, Pei; Lou, Hong-Xiang
- Abstract
Three new sorbicillinoids, including trimer trisorbicillinone E (1), acremosorbicillinoids A and B (2 and 3), and a new alkaloid acremokaloid A (4), and a new natural product 2 S ,3 S -acetyl-β-methyltryptophan (5), were isolated from an endophytic fungus Acremonium citrinum SS-g13, which is found in Fructus mori plant root. In addition, eight known sorbicillinoids (6–13) were also obtained. The new compound structures were established using NMR, HRESIMS spectra, and reported spectroscopic data. The absolute configurations of compounds 1–5 , were determined by spectroscopic analysis, Snatzke's method, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. Compound 11 exhibited significant cholesterol efflux enhancing activity. A plausible biosynthesis pathway for the sorbicillinoids is discussed.
- Subjects
ENDOPHYTIC fungi; ACREMONIUM; CIRCULAR dichroism; PLANT roots; NATURAL products; POLYKETIDES
- Publication
Frontiers in Microbiology, 2022, Vol 13, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2022.800626