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- Title
Risks of central nervous system infections and related mortality in patients undergoing dialysis.
- Authors
Hsu, Chueh‐Hsuan; Hsu, Chueh‐Lin; Shiu, Yu‐Neng; Lin, Po‐Chang; Huang, Hung‐Yu; Lin, Shih‐Yi; Lin, Cheng‐Li; Yu, Tung‐Min; Yen, Tzung‐Hai; Li, Chi‐Yuan; Wang, I‐Kuan
- Abstract
Introduction: This study aimed to investigate the risks of central nervous system (CNS) infections and related mortality in patients with end‐stage renal disease (ESRD) undergoing dialysis. Methods: Incident dialysis patients were identified from 2000 to 2013. The risks of CNS infection and related mortality were analyzed. Results: The adjusted hazard ratio (HR) of CNS infection in the ESRD group compared with the control group was 3.46 (95% confidence interval [CI] 2.75–4.35). The adjusted odds ratio (OR) of 90‐day mortality following CNS infections in the ESRD group in comparison with the control group was 5.99 (95% CI 2.78–12.9). The adjusted HR of overall CNS infection for the peritoneal dialysis (PD) group in comparison with the hemodialysis (HD) group was 1.07 (95% CI 0.63–1.82). Influenza vaccination was associated with a lower risks of CNS infection in dialysis patients (adjusted HR: 0.38, 95% CI 0.30–0.48). The adjusted OR of 90‐day mortality following CNS infection for the PD group in comparison with the HD group was 1.01 (95% CI 0.55–1.87). Conclusions: The risks of CNS infections and related mortality were remarkably high in dialysis patients with no significant difference between patients with ESRD under HD and PD treatment.
- Subjects
CENTRAL nervous system infections; HEMODIAFILTRATION; HEMODIALYSIS patients; CHRONIC kidney failure; CENTRAL nervous system; PERITONEAL dialysis
- Publication
Seminars in Dialysis, 2022, Vol 35, Issue 4, p317
- ISSN
0894-0959
- Publication type
Article
- DOI
10.1111/sdi.13058