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- Title
Dietary mushroom (Pleurotus ostreatus ) ameliorates atherogenic lipid in hypercholesterolaemic rats.
- Authors
Hossain, Shahdat; Hashimoto, Michio; Choudhury, Emran Kabir; Alam, Nuhu; Hussain, Shahjalal; Hasan, Moynul; Choudhury, Shahabuddin Kabir; Mahmud, Ishtiaq
- Abstract
Summary 1. The effects of edible oyster mushroom Pleurotus ostreatus on plasma and liver lipid profiles and on the plasma total anti-oxidant status were estimated in hyper- and normocholesterolaemic Long Evans rats. 2. The feeding of 5% powder of the fruiting bodies of P. ostreatus mushrooms to hypercholesterolaemic rats reduced their plasma total cholesterol by approximately 28%, low-density lipoprotein–cholesterol by approximately 55%, triglyceride by approximately 34%, non-esterified fatty acid by approximately 30% and total liver cholesterol levels by > 34%, with a concurrent increase in plasma high-density lipoprotein–cholesterol concentration of > 21%. However, these effects were not observed in mushroom-fed normocholesterolaemic rats. 3. Mushroom feeding significantly increased plasma fatty acid unsaturation in both normo- and hypercholesterolaemic rats. 4. Plasma total anti-oxidant status, as estimated by the oxidation of 2,2′-azino-bis-[3-ethylbenz-thiazoline-6-sulphonic-acid], was significantly decreased in mushroom-fed hypercholesterolaemic rats, concomitant with a decrease in plasma total cholesterol. 5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.
- Subjects
PLEUROTUS ostreatus; RATS; CHOLESTEROL; BLOOD plasma
- Publication
Clinical & Experimental Pharmacology & Physiology, 2003, Vol 30, Issue 7, p470
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1046/j.1440-1681.2003.03857.x