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- Title
Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese.
- Authors
Ting Kin Cheung; Wai Man Wong; Wong, Nina Y. H.; Chi Kuen Chan; Fung, James; Man Fung Yuen; Chan, Annie O. O.; Tong, Teresa S. M.; Wong, Benjamin C. Y.
- Abstract
Background: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG, Basel
- Subjects
GASTROESOPHAGEAL reflux; ESOPHAGUS diseases; PROTON pump inhibitors; ESOMEPRAZOLE; ENDOSCOPY
- Publication
Digestion, 2007, Vol 75, Issue 2/3, p128
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000106453