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- Title
Trends and disease burden of enteric fever in Guangxi province, China, 1994--2004.
- Authors
Bai-Qing Dong; Jin Yang; Xuan-Yi Wang; Jian Gong; von Seidlein, Lorenz; Ming-Liu Wang; Mei Lin; He-Zhuang Liao; Ochiai, R. Leon; Zhi-Yi Xu; Jodar, Luis; Clemens, John D.
- Abstract
Objective: To determine the burden of enteric fever through trends in morbidity and mortality, bacterial species and antimicrobial resistance in Guangxi, a southern, subtropical, coastal province of China with a disproportionally large burden of enteric fever. Methods: Data on morbidity and mortality caused by enteric fever between 1994 and 2004 were extracted from the Guangxi Center for Disease Control and Prevention. Laboratory-based surveillance and outbreak investigations were integrated with reports of notifiable infectious diseases to estimate the bacterial species-specific incidence of enteric fever. To adjust for underreporting, survey data were collected from three prefectures that represent the hyper-, moderate- and low-endemic regions of Guangxi province. Findings: In Guangxi province, enteric fever incidence rate varied over the study period, with a peak of 13.5 cases per 100 000 population in 1995 and a low of 6.5 in 2003. The disease occurred most frequently during the summer and autumn months and in the group aged 10-49 years. The incidence of enteric fever varied by region within Guangxi province. During the 11-year period covered by the study, 61 outbreaks of enteric fever were reported, and Salmonella paratyphi A (SPA) became the predominant causative agent in the province. Conclusion: Prospective studies may provide a better understanding of the reason for the shifting epidemiology of enteric fever in Guangxi province. Given the emergence of resistance to first- and second-line antimicrobials for the treatment of enteric fever, a bivalent vaccine against both SPA and S. typhi would facilitate for disease control.
- Subjects
GUANGXI Zhuangzu Zizhiqu (China); CHINA; TYPHOID fever; DISEASE prevalence; DISEASES &; society; PUBLIC health surveillance; DISEASE incidence; MORTALITY; DATA analysis
- Publication
Bulletin of the World Health Organization, 2010, Vol 88, Issue 9, p689
- ISSN
0042-9686
- Publication type
Article
- DOI
10.2471/BLT.09.069310