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- Title
Comparison of Low Dose Magnesium Sulphate Versus Standard Regime in Severe Preeclampsia.
- Authors
Nayek, Himadri; Hassan, Faruk; Mondal, Satabdi; Ray, Hari Charan
- Abstract
Background: Because to hypoproteinemia, malnutrition, and inadequate obstetric facilities, the incidence of hypertensive diseases during pregnancy, such as PE and eclampsia, is high in developing nations. MgSO4 is the mainstay of preeclampsia and eclampsia treatment, and the Pritchard regimen is the most often used. Aims: To compare statistically the efficacy of two different preventive Magnesium Sulphate regimes in avoiding eclampsia when administered to 150 severely preeclamptic women at random. The major goal is to compare the two regimes in terms of their safety profile by comparing the adverse feto-maternal consequences when utilized in severe preeclampsia. This should be regarded as the study's secondary goal. Materials and methods: The present study was a hospital-based Retro-spective comparative study. This Study was conducted from 1 year at Department of Obstetrics and gynaecology; Midnapore Medical College and Hospital. Total 100 patients were included in this study. Result: In Group - A, Delivery mode of 16 (32%) patients were vaginal, Delivery mode of 11 (22%) patients were LSCS and Delivery mode of 15 (30%) patients were Live. In Group - B, Delivery mode of 20 (40%) patients were vaginal, Delivery mode of 15 (30%) patients were LSCS and Delivery mode of 6 (12%) patients were Live. In Group - A, 12 (24%) patients had taken time of recurrent convulsion within 5 min, 22 (44%) patients had taken time of recurrent convulsion within 15 min, 9 (18%) patients had taken Time of recurrent convulsion within 1 hour and 7 (14%) patients had taken Time of recurrent convulsion within 4 hour. In Group - A, 21 (42%) patients had taken time of recurrent convulsion within 5 min, 15 (30%) patients had taken time of recurrent convulsion within 15 min, 6 (12%) patients had taken Time of recurrent convulsion within 1 hour and 8 (16%) patients had taken Time of recurrent convulsion within 4 hour. Association of Time of recurrent convulsion (interval after loading dose) with Group was not statistically significant (p=0.2172). In Group - A, 33 (66%) patients were in control group and 17 (34%) patients were in study group. In Group - B, 22 (44%) patients were in control group and 28 (56%) patients were in study group. Association of Recurrence of convulsions with Group was statistically significant (p=0.027). Conclusion: We conclude that efficacy of reduced loading dose regimen (omitting IV loading dose) and 12 hour maintenance dose of MgSo4 is similar to standard Pritchard regimen (which employs full loading dose and 24 hour maintenance dose) in both prophylaxis of convulsion in severe preeclampsia and controlling convulsion and preventing recurrent convulsion in eclampsia with the obvious lower propensity for MgSo4 toxicity.
- Subjects
MAGNESIUM sulfate; ECLAMPSIA; DELIVERY (Obstetrics); PREECLAMPSIA; DRUG dosage; DEVELOPING countries
- Publication
European Journal of Cardiovascular Medicine, 2024, Vol 14, Issue 1, p1091
- ISSN
2042-4884
- Publication type
Article