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- Title
Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease.
- Authors
Bonalume Tácito, Lúcia Helena; Nakachima Yamada, Lilian; de Souza Pinhel, Marcela Augusta; Yugar-Toledo, Juan Carlos; Silva Souza, Dorotéia Rossi
- Abstract
This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.
- Subjects
BRAZIL; DIAGNOSIS; CORONARY disease; CORONARY heart disease risk factors; ALLELES; APOLIPOPROTEINS; CHOLESTEROL; DYNAMICS; GENETIC polymorphisms; HEALTH outcome assessment; PATIENTS; TRIGLYCERIDES; CONTROL groups; POSTMENOPAUSE; GENOTYPES
- Publication
Clinical Medicine Insights: Cardiology, 2017, Vol 11, p1
- ISSN
1179-5468
- Publication type
Article
- DOI
10.1177/1179546817731110