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- Title
Uterine Tumour Resembling Ovarian Sex-Cord Tumour with True Sex-Cord Differentiation.
- Authors
Jain, Manjula; Madan, Neha Kawatra; Singh, Smita
- Abstract
Uterine tumours are diagnosed in the majority of cases using light microscopy. In some cases, extensive immunohistochemical analysis is needed to properly categorize these tumours. The authors present a rare case in a 50-year-old woman who had a submucosal polypoid growth in the uterine fundus that showed a circumscribed tumour arranged in sheets and nests of small oval to plump spindle cells. In places, tumour cells were more round to cuboidal, arranged in tubules, anastomosing cords, and trabeculae. Immunohistochemically, the cells showed diffuse and strong cytoplasmic positivity for cairetinin, CD99, and vimentin and diffuse nuclear positivity for progesterone receptor. Focal positivity for cytokeratin and estrogen receptor and focal weak positivity for inhibin and CD 10 were noted, whereas epithelial membrane antigen, carcinoembryonic antigen, smooth muscle actin, and desmin were not expressed. The findings provided strong evidence of true sex-cord differentiation. The final diagnosis was uterine tumour resembling ovarian sex-cord tumour (with true sex-cord differentiation), infiltrating less than half of the myometrium.
- Subjects
CERVIX uteri tumors; OVARIAN tumors; TREATMENT of diseases in older women; MICROSCOPY; IMMUNOHISTOCHEMISTRY
- Publication
Canadian Journal of Pathology, 2012, Vol 4, Issue 4, p126
- ISSN
1918-915X
- Publication type
Case Study