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- Title
The role of FZR1 in tumorigenesis: Focus on cell-cycle control.
- Authors
HUI LI; CHENGFANG ZHOU; MEI KUANG; YUN LIU; JIEPING CHEN
- Abstract
Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlight recent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability through cell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinct ways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches for targeting the FZR1 as a cancer therapy and research area for future work.
- Subjects
CANCER treatment; CANCER cell growth; CELL cycle; ANAPHASE; HEMATOLOGIC malignancies
- Publication
Biocell, 2023, Vol 47, Issue 10, p2177
- ISSN
0327-9545
- Publication type
Article
- DOI
10.32604/biocell.2023.029373