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- Title
Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials.
- Authors
Gandasegui, Javier; Martínez-Valladares, María; Grau-Pujol, Berta; Krolewiecki, Alejandro J.; Balaña-Fouce, Rafael; Gelaye, Woyneshet; van Lieshout, Lisette; Kepha, Stella; Mandomando, Inácio; Muñoz, José
- Abstract
Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials In veterinary medicine, benzimidazole resistance is mainly associated with a single nucleotide polymorphism (SNP) at codon 200 of isotype 1 of -tubulin-encoding gene, which results in amino-acid substitution of phenylalanine to tyrosine (F200Y). 19 Rashwan N, Bourguinat C, Keller K, Gunawardena NK, de Silva N, Prichard R. Isothermal diagnostic assays for monitoring single nucleotide polymorphisms in I Necator americanus i associated with benzimidazole drug resistance. Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol.
- Subjects
NEMATODE infections; RESTRICTION fragment length polymorphisms
- Publication
PLoS Neglected Tropical Diseases, 2020, Vol 14, Issue 2, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0007931